Senior Research Scientist
Cheryl Clarkson, DMD, PhD joined GW in 2017 as a research scientist at GWNIC. Her PhD training at University of Salamanca was centered on understanding the homeostatic plasticity in the brainstem after sensorial deprivation, using a variety of neuroanatomical, microscopic, genetic and physiological techniques. Her postdoctoral appointment at University of Pittsburgh was focused in changes at pre/postsynaptic neuronal and glial components after temporal deprivation; she was using mostly ultrastructural/molecular analyses at the electron microscopic level, including freeze substitution, postembedding immunogold labeling and serial section 3D reconstructions.
At the GWNIC she has been involved in experiments dedicated to demonstrating, using high technology FibSEM/3D reconstruction approaches, the development of a new procedure for generating miniature 3D versions of the brain called “organoids” from human stem cells, creating the first organoids capable of myelination, modeling the brain’s structure and function more closely than ever. Cheryl has been developing biological experiments for correlative light and electron microscopy (FibSEM) to localize and identify different types of cells with particular ultrastructure characteristics and also working as part of a team to design an innovative image analysis workflow for mining SEM+ postembedding images to quantify proteins expression at different areas of the brain.
Her work has been published in several peer-reviewed neuroscience journals.